The majority of API candidates under clinical development are poorly water-soluble, and they can be sensitive to hydrolysis or adverse reactions triggered by impurities. Water-free formulating may be an idea that derives from technical needs, but it offers a multitude of possibilities. For example, depending on product presentation, a water-free system may not require preservation or other stabilizers.
Petrol-based formulations have been and will remain a staple in the toolbox of topical formulation development. However, an occlusive nature, formulation aesthetics or skin feeling may not be beneficial to the targeted mode of action and patient compliance in chronic application regimes.