A new generation of lipid based excipients
A new generation of lipid based excipients
What if a new generation of lipid-based excipients could lift advanced pharmaceutical drug development with poorly soluble APIs to its next level
by providing a built-in fit-for-purpose feature for advanced processes such as hot melt extrusion, hot melt coating, particle engineering and 3D-printing?
More than 75% of new chemical entities are poorly soluble and require bioavailability-enhancing excipients. The application of excipients in advanced pharmaceutical processes, aligned with advanced approaches towards personalized medicine, requires special features. Lipid-based excipients (LBEs) are „natural contenders“ for the tasks. However, until now, it has not been possible to fully exploit the potential of LBEs. The main challenge is the unstable solid state of current LBEs, e.g. polymorphism, leading to instability of the final dosage form. Compared to polymers, the low melting temperature of liquids, combined with highly crystalline arrangement, limits their application in advanced pharmaceutical processes.
Reason why
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How this new generation of LBEs could serve your fit for purpose needs is described in the
publications and posters listed below.
Novel approach for overcoming the stability challenges of lipid-based excipients
Part 1: Screening of solid-state and physical properties of polyglycerol esters of fatty acids as advanced pharmaceutical excipients
Carolina Corzo a,b, Diogo Gomes Lopes a, Dirk Lochmann c, Sebastian Reyer c, Michael Stehr c, Sharareh Salar-Behzadi a,b
Novel approach for overcoming the stability challenges of lipid-based excipients
Part 2: Application of polyglycerol esters of fatty acids as hot melt coating excipients
Sharareh Salar-Behzadi a, Carolina Corzo a, Diogo Gomes Lopes a, Claudia Meindl c, Dirk Lochmann d, Sebastian Reyer d
Novel approach for overcoming the stability challenges of lipid-based excipients
Part 3: Application of polyglycerol esters of fatty acids for the next generation of solid lipid nanoparticles
Carolina Corzo a,b, Claudia Meindl c, Dirk Lochmann d, Sebastian Reyer d, Sharareh Salar-Behzadi a,b
Eleonore Fröhlich a,b, Kristin Öhlinger b, Claudia Meindl b, Carolina Corzo c, Dirk Lochmann d, Sebastian Reyer d, Sharareh Salar-Behzadi a,c
Carolina Corzo a,b, Diogo Gomes Lopes a, Dirk Lochmann c, Sebastian Reyer c, Michael Stehr c, Sharareh Salar-Behzadi a,b
Sharareh Salar-Behzadi a, Carolina Corzo a, Diogo Gomes Lopes a, Claudia Meindl c, Dirk Lochmann d, Sebastian Reyer d
Carolina Corzo a,b, Claudia Meindl c, Dirk Lochmann d, Sebastian Reyer d, Sharareh Salar-Behzadi a,b
Eleonore Fröhlich a,b, Kristin Öhlinger b, Claudia Meindl b, Carolina Corzo c, Dirk Lochmann d, Sebastian Reyer d, Sharareh Salar-Behzadi a,c
If you have further specific needs or questions or in case you have already been confronted with the unstable solid state of existing LBEs in your formulation, we are happy to support you to overcome the challenge of polymorphism.
Please don´t hesitate to contact us.
